The Dutchman has scored in Bayern's last five Champions League fixtures, a streak that includes their 2-1 win over Borussia Dortmund in the 2012-13 final at Wembley in May.
Only three players in the history of Europe's premier club competition have scored in six successive fixtures and Robben will aim to join Marouane Chamakh, Burak Yilmaz and Cristiano Ronaldo in achieving the feat.
Bayern's 33-match unbeaten streak in the Bundesliga came under threat when Shawn Parker's goal helped Mainz to the lead at the break.
However, Mario Gotze came on at half-time and helped to change the match, as two goals from Thomas Muller and additional strikes from Robben and Mario Mandzukic carried Pep Guardiola's side to victory.
Winger Franck Ribery was rested as a precaution, but the Frenchman is likely to be fit for Wednesday's clash.
"It's nothing serious. I wanted to play, but the doctor said it was too much of a risk," Robben said.
Defender Jerome Boateng is suspended following his red card in Manchester and although midfielder Javi Martinez has returned to training following groin surgery, Wednesday's match will come too soon for him.
Centre-back Marian Cisovsky missed both of those defeats due to a calf injury but returned in Saturday's 1-1 draw with Sparta Prague.
David Limbersky, another member of Plzen’s defence, has not played in almost a month due to a thigh injury and is set to miss out again.
