UEFA Champions League: Basel v Liverpool
Sturridge has not featured in his club's last five matches after sustaining a thigh injury while on international duty with England at the beginning of September.
The striker - scorer of 36 goals in 52 Liverpool appearances since joining from Chelsea in January 2013 - has been sorely missed by Brendan Rodgers' stuttering side who, as yet, have failed to hit the heights of last season.
Liverpool have made an unconvincing start to the campaign, taking just seven points from their opening six Premier League games and requiring an injury-time penalty from captain Steven Gerrard to beat Ludogorets 2-1 in their Champions League opener a fortnight ago.
But their talisman Sturridge is edging closer to a much-anticipated return - with Rodgers revealing in the aftermath of Liverpool's 1-1 draw with Everton on Saturday that the 25-year-old could feature in Switzerland.
"He wasn't really close for this game [the Merseyside derby]," said the Northern Irishman.
"I'll see how he is [for Basel]. He wasn't far away for Everton, but he certainly wasn't fit enough to be on the bench.
"Daniel is obviously a top talent - and he's not far away from being back playing."
Sturridge is one of a number of Liverpool players currently struggling with injury, and Rodgers looks set to be without Emre Can (ankle), as well as Glen Johnson and Joe Allen (both knee), at St Jakob-Park.
Mario Balotelli, who scored his first Liverpool goal in the victory over Ludogorets, is likely to lead the line once again.
In contrast to Liverpool’s domestic struggles, Basel go into Wednesday's clash top of the Swiss Super League.
However, Paulo Sousa's team were thumped 5-1 by Real Madrid in their first group game, as the reigning European champions ran riot in the first half at the Santiago Bernabeu.
That result makes Wednesday's fixture even more crucial for Basel, with Sousa's men widely expected to be in a two-way battle with Liverpool for second place in Group B behind Real.
History is on Basel's side, though, as Liverpool - and Gerrard in particular - do not have fond memories of St Jakob-Park.
A below-par Gerrard was substituted at half-time in his side's last visit to Basel back in November 2002 - a game Liverpool needed to win to qualify from their Champions League pool.
Basel stormed into a 3-0 lead after just 29 minutes and, although a second-half fightback enabled Liverpool to draw 3-3, that was not enough to prevent their elimination to the UEFA Cup.
Some 12 years on, Gerrard - the only surviving member of that Liverpool team - is sure to be determined to make amends for what he has labelled one of the worst performances of his career.