The Spaniard managed Tottenham between 2007 and 2008, leading them to a League Cup title before being sacked with the London club rock-bottom of the Premier League.
Ramos is now in charge at Ukrainian side Dnipro and will hope to exact a measure of revenge on the club who dismissed him after less than a year at the helm.
Tottenham have lost just three of the 12 games since the dismissal of Andre Villas-Boas in December, with Sherwood reinvigorating a side whose hopes of reaching next season's Champions League had looked to be fading.
The London club are only three points behind Liverpool in the race for fourth place in the Premier League, but they will now switch focus to the Europa League as they seek to add the title to the two UEFA Cup crowns already on the club's honours list.
"I love it (the Europa League)," Sherwood said. "There are a lot of games coming up but we haven't got to worry about that.
"We're out of the rest of the competitions and we've got a big enough squad here to cope.
"There will be opportunities for other people to play because the games will come thick and fast and you're playing on Thursday and Sunday."
Dnipro, meanwhile, will look to the likes of winger Yevhen Konoplyanka – the subject of a failed approach from Liverpool in January – and strikers Roman Zozulya and Yevhen Seleznyov to help guide them to a shock triumph.
