Garry Monk's men turned in one of their best performances of the season last Thursday to give themselves a fighting chance heading to the Stadio San Paolo.
Indeed, the only thing missing from the Welsh side's display was a goal - something they will be looking to rectify in Italy.
Rafael Benitez's side have four wins from their last 10 fixtures, but the Spaniard insists their continued involvement in three competitions is not having an adverse effect.
"It is not a physical issue at all," he said. " The team is good and all staff are involved in both the championship and Coppa Italia - the players know they have to distribute energy.
"Swansea played a great game against Liverpool in the weekend’s Premier League fixtures, despite losing a very close contest.
"They could make things very difficult. We must be prepared to go the distance."
In Michu's absence, Wilfried Bony has shouldered greater responsibility for Swansea and the Dutch forward heads to Italy in form, having scored twice at Liverpool to take his tally for the season to 19 in all competitions.
