Benzema has been playing in the Spanish league with Real Madrid since 2009 and five of his team-mates are in the Spain squad for the game at the Donbass Arena.
One of those, defender Sergio Ramos, warned the holders need to be on the guard against a player who struck 31 goals in all competitions for Real last season.
"I've spoken to him, we have a great relationship and keep in touch by phone," Ramos said.
"Maybe he didn't have a great beginning [to his career at Real] but he's a great forward. Even though he hasn't scored yet [at Euro 2012], he works hard for the team and if take your eye off him, he will score."
"Benzema has had a great season for Real Madrid, he is a great forward, he is very accurate when he goes for goal and also a very consistent player," he said.
"I don't think France will just close their defence, they have strong midfielders, they know how to use the ball and in any case we can change our style a little to use what they offer us," said forward Juan Mata.
"A long time has passed since that game, our team then was different, we were very young and didn't have the international experience that we have now," he said.
"I think we have matured now and that is important. Whether it is World Cup or a Euro our philosophy is successful and we respect all our opponents which is a fundamental for us," he said.
