Michel Preud'homme's Brugge are chasing an unprecedented treble as they sit at the top of their domestic league having already won the Belgian Cup against Anderlecht last month.
But they will have to retain their interest in continental glory with a positive result in Ukraine next week, against opponents who produced the sharper work this time out.
Dnipro captain Ruslan Rotan spurned a good chance to put his team in front when lofted over from Valeriy Luchkevych's 10th-minute cutback.
Yevhen Konoplyanka was at the heart of much of Dnipro's early impressive work and he drove at the home defence before unleashing a blocked shot that prompted a penalty box scramble.
The game's first clear opening fell Brugge's way as Obbi Oulare - preferred to Tom De Sutter in attack - dropped deep to thread a superb throughball into Izquierdo's path. The winger broke free of the Dnipro defence but goalkeeper Denys Boyko stood firm to deny him.
Preud'homme's men began the second period with greater intent and Davy de Fauw - who endured a torrid first half defensively - was left unattended to head a 47th-minute corner wide.
Dnipro showed their prowess on the break a few moments later but Kalinic could not make contact with Rotan's cross-shot.
A flurry of yellow cards either side of the hour hindered the game's flow but both teams pressed gamely for the breakthrough - making light of their respective pre-match injury struggles.
Rotan came close to finding it once more, with Brugge's Mat Ryan grasping his 77th-minute header at the second attempt.
