Ahmed Musa put hosts VVV ahead early in the second half, netting from close range after good work from fellow Nigerian Michael Uchebo (pictured) before adding a second on the hour.
Skipper Theo Janssen pulled one back for a lacklustre Ajax after 68 minutes with a well-placed long drive and two minutes later Kolbeinn Sightorsson grabbed the equaliser.
Twente Enschede are top of the table with maximum points after three matches following their 5-1 thrashing of Heerenveen on Saturday. Ajax, Feyenoord and Vitesse Arnhem follow on seven points.
Feyenoord also dropped their first points in a 1-1 draw at Heracles Almelo, who had gone ahead through Glynor Plet before Guyon Fernandez salvaged a point 12 minutes from time.
PSV Eindhoven cruised to a 3-0 win at ADO Den Haag with first-half goals by Dries Mertens, Georginio Wijnaldum and Ola Toivonen, while U.S. international Jozy Altidore hit a double to set up a 4-0 home victory for AZ Alkmaar over NEC Nijmegen.
