Fellow Paraguayan Dante Lopez also scored two as title holders Pumas UNAM ended a run of five defeats with their first win of the Apertura, the first of two tournaments in the season, when they beat promoted Queretaro 3-0.
"It was the perfect match," America's Argentine playmaker Daniel Montenegro, who lobbed goalkeeper Hernan Cristante from the halfway line for his team's sixth goal, told Televisa.
Mexico midfielder Pavel Pardo began the rout with a shot from outside the box that went in close to the base of the post and America were five up by halftime.
They eased off in the second half and conceded two goals to Toluca's Chilean forward Hector Mancilla, the second a penalty.
Pumas had scored just one goal and conceded 12 in their previous five matches, but seemed to break the spell in midweek when they won a CONCACAF Champions league match 5-1 against Real Espana of Honduras.
They remain, however, bottom of Group Three which is led by Cruz Azul after their surprise 3-0 away victory over Morelia.
Morelia have the same number of points as America but are behind them in the Group Two standings on goal difference.
Toluca, despite their thrashing, remain top of Group One by five points from second-placed Atlas.
