Jens Keller's men welcome Dortmund to the Veltins Arena knowing victory could see them move into the top four as they look to recover from a difficult start to the campaign.
And the hosts should take confidence from their performances last season, when they took maximum points from both their encounters with Jurgen Klopp's charges.
Dortmund are in superb form going into the contest, having lost just two of their last 14 games in all competitions.
Klopp is eager to atone for last year's defeats to Schalke, which he said hurt more than losing out to Bayern Munich in the Bundesliga and the UEFA Champions League.
"When you sign a contract at Borussia Dortmund, the first thing you learn is that there are 32 Bundesliga games and two derbies," he said.
"The results last year hurt me the most. If we had played better, the results would have been better. Those defeats are the dark clouds over our last campaign, which, even without a title, was still pretty good otherwise."
