Werder Bremen and Hoffenheim played out a 1-1 draw in their relegation six-pointer at the Weserstadion as Julian Nagelsmann's first match in charge ended level.
Nagelsmann was appointed Hoffenheim boss on Thursday following health troubles for predecessor Huub Stevens and is the youngest head coach in Bundesliga history at 28-years-old.
Chelsea loanee Papy Djilobodji levelled matters just three minutes later, with Kramaric's late dismissal unable to tip the scales in Bremen's direction.
Alexander Meier got Frankfurt off to a strong start 24 minutes into coach Armin Veh's 300th Bundesliga outing but Yannick Gerhardt equalised soon after before Dominique Heintz and Anthony Modeste sealed the points after the break.
Hertha Berlin's stuttering recent form continued as their winless Bundesliga run was extended to four matches courtesy of a 2-0 defeat at Stuttgart.
Missing leading goalscorer Javier Hernandez due to injury, Leverkusen fell behind to Sandro Wagner's 28th-minute opener.
However, an Aytac Sulu own goal followed by Julian Brandt's winner put Roger Schmidt's men in pole position for the final automatic Champions League spot.
