Loanee Iago Aspas scored a sensational hat-trick in the space of four minutes at the Estadio Ramon Sanchez Pizjuan as Sevilla crushed second-tier outfit Sabadell 11-2 on aggregate.
Sabadell took a surprise 22nd-minute lead courtesy of Juan Collantes' penalty after Sevilla defender Timothee Kolodziejczak fouled the Spanish midfielder.
Defending La Liga champions Atletico scored three second-half goals to beat Segunda B team L'Hospitalet in their first-leg clash.
Antoine Griezmann ghosted into the penalty area 20 minutes after coming on at half-time to head Diego Simeone's side in front from close range in the round of 32 tie.
Gabi's 81st-minute penalty doubled Atletico's lead before Cristian Rodriguez added a third goal for the visitors in stoppage time.
Ivan Rakitic was the driving force in Barca's midfield and his tremendous free-kick opened the scoring, before Andres Iniesta - playing his first match since October 25 due to a calf injury - grabbed his first goal of the season with an excellent finish.
Pedro effectively ended the game as contest with a fierce drive seven minutes before the break, and Rafinha made it four in the second half with his first Barca goal - albeit with the help of a huge deflection.
In other first-leg fixtures on Wednesday, Toche's 68th-minute equaliser earned hosts Deportivo La Coruna a 1-1 draw with Malaga.
