Colo-Colo boosted their chances of reaching the Copa Libertadores knockout stage, while Cruzeiro made it back-to-back wins.
After kick-off was delayed due to lighting issues at the Estadio Jocay in Manta, Colo-Colo recorded a 2-1 win over Delfin in Group 2.
Esteban Paredes converted a penalty on the stroke of half-time for Colo-Colo, who saw out a win despite Luis Chicaiza's 79th-minute strike for the hosts.
The win was Colo-Colo's first in the group as they moved onto four points, just one adrift of second-placed Bolivar with two games remaining.
NOTA | El Cacique gana un partido vital en Manta May 3, 2018
In Rio de Janeiro, Cruzeiro claimed a comprehensive 4-0 win over Vasco da Gama.
Less than a week after crushing Universidad de Chile 7-0, Cruzeiro were once again in rampant form.
Egidio was the star for the visitors, setting up Leo's 10th-minute opener before teeing up Thiago Neves.
Sassa made it 3-0 shortly after the half-hour mark, receiving a pass from Egidio before unleashing a stunning 30-yard strike.
The win was sealed early in the second half through Sassa as Cruzeiro moved top of Group 5.
. fue contundente ante (4-0) y pone un pie en los octavos de la May 3, 2018
Boca Juniors are in danger of making a group-stage exit after a 1-1 draw at Junior left them third in Group 8 with a game to play.
Independiente climbed into second in Group 7 with a 2-1 win at Corinthians and Atletico Tucuman edged Penarol 1-0 in Group 3.
