Roda sit bottom of the table heading into their trip to Go Ahead Eagles on Saturday, and will need a win to avoid dropping into the Eerste Divisie.
Jon Dahl Tomasson's men also require NEC, who sit three points ahead in 17th, to lose at Ajax and a three-goal swing in goal difference in order to secure a place in the relegation play-offs at the expense of Anton Janssen's side.
Ajax may have already clinched a fourth consecutive Dutch title, but they are unlikely to be short of motivation in what could be coach Frank de Boer's final game in charge of the capital club.
De Boer revealed on Tuesday that he is considering an approach from Tottenham for his services, although the Premier League club have since denied that they have enquired with Ajax over the 43-year-old's availability.
Even then, Erwin Koeman's men would need a significant swing in goal difference to avoid having to go through the play-offs to stay up.
PSV lead Vitesse by a point and Heerenveen by two in the race for the final automatic Europa League spot, and only need to win to ensure their qualification for Europe's second-tier club competition.
Ronald Koeman will take charge of his final game as Feyenoord boss when the Rotterdam club travel to AZ, while Twente welcome KNVB Beker winners PEC Zwolle to De Grolsch Veste.
