Old Trafford will play host to the most successful clubs in the competition’s history, after Arsenal's win over Hull City last year brought them level with United on 11 FA Cup triumphs apiece.
And Wenger knows that the team to prevail from this tie will strongly fancy their chances of bringing up number 12 at Wembley in May.
"It is a [game with] special intensity because it is between two teams who have a chance to win this competition," the Arsenal boss told his pre-match media conference.
"Both teams will think: 'If we get over this hurdle, we have a good opportunity to win the competition'."
The rivalry between United and Arsenal intensified in the modern era as Wenger led a succession of battles for the Premier League title against old nemesis Alex Ferguson.
Wayne Rooney has secured nine major honours during his time at Old Trafford, but does not count an FA Cup winners' medal among his collection.
"We haven't been to a final for a few years, we want to try to win that game and we are looking forward to that," he told United's official website
"Of course, I think it is a massive trophy. It is a trophy that, growing up as a youngster, I used to love watching and I was fortunate enough to see Everton lift the FA Cup in 1995 when I was nine years old. It is something which I would love to do and hopefully it can be this year."
Gabriel Paulista misses out for Arsenal due to a hamstring injury that is set to keep him on the sidelines for around three weeks, while United's Jonny Evans begins a six-match suspension for his involvement in a spitting incident with Newcastle United striker Papiss Cisse in midweek .
