Fresh from a critic-silencing hat-trick against German side VfL Wolfsburg in Tuesday's 3-1 Champions League win, Michael Owen will be hoping to figure alongside fit-again Wayne Rooney or Dimitar Berbatov.
England striker Rooney, who has 11 league goals this season, is expected to return from a hamstring injury, while Bulgarian international Berbatov has overcome a knee problem.
"We expect Vidic to be ready for Saturday. Ryan (Giggs) is fit and I also think Rooney and Berbatov will both be okay," Ferguson told the club website.
"If I have that availability I am okay and I'll be happy enough because I can play a back four of (Darren) Fletcher, (Michael) Carrick, Vidic and (Patrice) Evra."
With defenders Rio Ferdinand, John O'Shea, Jonny Evans, Wes Brown, Gary Neville and the Da Silva brothers, Rafael and Fabio, all missing, an unusual back four could become somewhat familiar for United's next few games.
"We have a very difficult game on Saturday against Villa, they are always very hard to play against, but our form is good and you want that going into any game. Hopefully we can keep it going."
