Reinaldo Rueda's side have performed well in their campaign. With three games remaining, Ecuador are two points clear of fifth-place Uruguay and three points behind Chile with a game in hand.
However, Rueda's men go into their clash with Bolivia on the back of a 1-0 defeat to Colombia on Friday, a game in which Walter Ayovi missed a penalty.
While Ecuador harbour aspirations of being in Brazil next year, Bolivia find themselves bottom of the group with just two wins from their 14 matches and 10 points from a possible 42.
Gabriel Achilier will be suspended for Ecuador after being sent off against Colombia, the Emelec defender will serve a three-match ban after his straight red card in the 28th minute for bringing down Teo Gutierrez.
Bolivia's goalkeeper Sergio Galarza will be hoping to have a better game than he did on Friday, when he was punished for some costly mistakes.
