City have made the Etihad Stadium a fortress this season, winning all seven home games in the top flight and scoring 29 goals in the process.
Manuel Pellegrini's side have also only conceded twice at home in the Premier League and come into the game on the back of a stunning 3-2 win at Bayern Munich in the UEFA Champions League.
Arsene Wenger's charges suffered their first loss in seven games when Napoli beat them 2-0 in midweek, but they still qualified for the last 16 of the Champions League for the 14th season in a row.
The Londoners' reverse in Italy caused them to drop to second behind Borussia Dortmund in Group F, meaning they will face one of Barcelona, Real Madrid, Bayern, Atletico Madrid or Paris Saint-Germain in the first knockout round.
"We have done our job now we will give absolutely everything on Saturday morning (at City)," said the Frenchman.
"We will see what comes out of the draw and will assess that in February, because a lot can change on both sides, on us and the team we play against, so we need to put that to the back of our minds now and focus on the championship."
Arsenal have lost only once on their travels in the top flight this season - at City's local rivals Manchester United last month.
That victory was not enough to secure top spot in Group D, but Pellegrini's men have now won five of their last six games in all competitions and know a victory over Arsenal would leave them just three points adrift of their opponents at the top of the Premier League.
