The Frenchman was knocked out following an accidental collision with Romelu Lukaku late in the game at Goodison Park last week, but got up and finished the match - a decision that sparked huge controversy.
Despite condemnation from various quarters, manager Andre Villas-Boas defended the club and denied any wrongdoing, insisting his keeper was fine to play the remainder of Sunday's 0-0 draw.
But Villas-Boas confirmed on Friday that Lloris would be back between the sticks for the showdown with Alan Pardew's men.
Jermain Defoe will hope to be handed his first Premier League start since the 3-0 loss to West Ham on October 6 after he became the club's all-time leading scorer in European competition with a second-half penalty against Sheriff.
Roberto Soldado, a £26million close-season signing from Valencia, has been preferred since then but the Spaniard's six-goal haul is three shy of the total achieved by his English team-mate this term.
But the triumph over Jose Mourinho's charges, which came courtesy of second-half goals from French duo Yoan Gouffran and Loic Remy, lifted Alan Pardew's side into the top half for the first time since mid-September and they will be in buoyant mood.
Midfielder Cheick Tiote, who limped off eight minutes into the second half versus Mourinho's team, is also likely to feature after overcoming a muscle strain.
Tottenham continue to be without Danny Rose (foot) and Nacer Chadli (hamstring).
