Louis van Gaal's men have been far from impressive in their build-up to the tournament and looked below par once again in Amsterdam against their Welsh visitors, who were without star names including Gareth Bale and Aaron Ramsey.
Arjen Robben scored the opening goal of the encounter shortly after the half-hour mark, but chances were few and far between throughout.
And Chris Coleman's visitors had to be on high alert in the early stages as Robin van Persie – celebrating the ninth anniversary of his international debut - had the first chance of the encounter, but Wayne Hennessey got down well to deny his low drive from just inside the penalty area.
Robben dragged an effort wide of the right-hand post in the ninth minute, before Wales settled and began to put the hosts under pressure at the back – Van Gaal's men far from assured in defence.
However, just as the Netherlands' sluggish start was beginning to draw the ire of the home crowd, Robben burst into the penalty area only to see his strike deflected over by Chris Gunter.
Fulham's George Williams came off the bench to make his Wales debut and the Netherlands had Ron Vlaar to thank for denying the youngster an almost instant goal to go with it.
But it was the hosts who had the final say, as Robben – arguably his side's brightest player in these pre-tournament friendlies – found an unmarked Lens with a cross from the right, and the Dynamo Kiev man tapped home unmarked.
