A home win over mid-table Chievo, coupled with second-placed Roma failing to beat Cagliari in the capital, would hand Jose Mourinho's side the second part of a possible treble with the Champions League final against Bayern Munich awaiting on May 22.
Dutch playmaker Wesley Sneijder may miss the Chievo match after suffering another thigh injury five minutes into the 1-0 win over Roma on Wednesday which sealed their sixth Italian Cup.
"I got a kick on my leg and some blood came out, but I feel better now. At least I can walk so we will see what happens," he told Inter's TV channel.
"I'm very happy about my first cup in Italy. We can take two more this year and we have to go for it, but the most important one is the first one and now we have to keep focused and win two more titles."
Roma were in the driving seat for the title but last month's home defeat to Sampdoria could ultimately cost them.
Samp lead Palermo by two points so a win would send the 1992 European Cup runners-up into next season's Champions League qualifying round at the expense of bigger names such as Juventus and Fiorentina, who have flopped this term.
Luigi Del Neri's Sampdoria even have a chance of pipping AC Milan to the third automatic Champions League place.
