Sahin and Grosskreutz have both been long-term absentees with knee and thigh problems respectively, with coach Jurgen Klopp also having concerns over Bender and full-back Eric Durm.
Bender picked up a knock in training while Durm has played a number of times for the club's second string as he steps up his comeback from a groin injury.
"Sahin will not be available on Saturday but Bender will not be a problem," Klopp told a news conference.
"With Durm we must wait and see if he makes the weekend.
"I assume that Kevin Grosskreutz will be fully back after the international break [at the end of March]."
Klopp went on to suggest that Oliver Kirch could play a key role as he bids to maintain his side's upturn in form.
"Oliver Kirch is a valuable player for us. He usually comes into play with our offensive game," Klopp added.
"It makes perfect sense to have more defensive stability.
"Cologne's away form has dramatically improved."
