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Danny will miss out on the chance to represent Portugal at Euro 2016 as he requires surgery on a knee problem.
Attacking midfielder Danny sustained the injury in the first half of Zenit's 5-2 victory over Spartak Moscow on Saturday and was replaced by Javi Garcia after just 31 minutes.
Zenit estimate Danny will be sidelined for eight to nine months as a result, with the captain to miss their Premier League run-in and Portugal's European Championship campaign in France this year.
