Kuyt suffers serious ankle injury
The Liverpool forward had to come off just before the half-hour mark in the Group E match when he landed awkwardly after jumping for a ball with Sweden's Daniel Majstorovic.
"Dirk wanted to play on but our doctor prevented that and told me to substitute him," Netherlands coach Bert van Marwijk told a news conference after his side's 4-1 win.
"He is now in a hospital but following the doctor's first opinion it could be very serious and keep him sidelined for a long time."
The unlucky Kuyt had to pull out of the squad preparing for Euro 2012 qualifying matches in September after injuring his shoulder during a training session with the national team.