Gerardo Martino's men know they will retain their title if they win both of their remaining two matches after leaders Atletico Madrid and third-placed Real Madrid failed to take advantage of them drawing 2-2 at home to Getafe last week.
Atletico lost 2-0 at Levante 24 hours after Barca's draw, while Real only took a point from their match against Valencia and then drew 1-1 at Real Vallodolid in midweek.
Therefore, Barca sit three points adrift of Atleti and one ahead of Real, with the Catalan giants scheduled to host Diego Simeone's team on the final day of the season.
Fran Escriba's side are unbeaten in their last nine home Liga games, and know a point against Barca would assure their top-flight survival.
And Escriba is hopeful of providing yet another twist in the title race this weekend.
"We have to be more intense than in the game at the Camp Nou. I trust that we will score and we can win," he said.
