Crawley's Richie Barker was the first to go on Wednesday, with Sean O'Driscoll's tenure at Ashton Gate called to an end the following day.
Barker's fate was sealed by a seven-match winless run and Town will now look to get back to winning ways against second-bottom Crewe Alexandra, who are themselves without a victory in six.
The timing of O'Driscoll's dismissal raised a few more eyebrows as City appeared to be turning the corner, having lost just one of their last six league games.
Struggling Sheffield United are Orient's visitors, with Nigel Clough's side seeking just their second away victory of an unexpectedly poor campaign so far.
Rock-bottom Notts County will bid for a first win in five when Uwe Rosler's Brentford visit Meadow Lane, while play-off chasing Rotherham United welcome a Gillingham outfit with four wins from their last six.
In Sunday's only game, sixth-placed Bradford City travel to Boundary Park to take on Oldham Athletic.
