Kenny Jackett's table toppers are six points ahead of second-placed Brentford, who sealed the second automatic promotion spot with a 1-0 win over Preston North End on Good Friday.
But with just three games left to play, and taking into account Wolves' vastly superior goal difference, even a Brentford victory at MK Dons on Monday is unlikely to be enough to keep Mark Warburton's slim hopes of the title alive.
At the bottom, Stevenage are seven points adrift of safety and defeat at home to mid-table Bristol City would confirm their relegation, while Carlisle United visit Peterborough United for a match that could hold huge significance at both ends of the table.
Darren Ferguson's Peterborough will look to bounce back from their 1-0 loss at Bradford City to re-assert their play-off credentials, while their conquerors on Friday could have a further say on whether the Football League Trophy winners finish in the top six.
Defeat would be another body blow for Graham Kavanagh's team, who are fourth bottom and two points from safety after Walsall's Michael Ngoo netted late on to secure a 1-1 draw last time out.
Shrewsbury will hope Preston's minds are already on other things as they head to Deepdale five points from safety with three games remaining.
