Wilder takes charge of Northampton for the first time at the weekend following his decision to leave promotion-hopefuls Oxford United in favour of moving to Sixfields.
And Northampton fans are hoping the arrival of Wilder can prove the catalyst for a change in fortunes as the side sit bottom of the Football League, six points adrift of safety.
Paul Cook's Chesterfield lead the way by one point, but the top seven are separated by just five points, so a third consecutive win could give the Derbyshire club some breathing space.
And even though Scunthorpe are undefeated in 12 league games, Russ Wilcox's men will have to end a run of three consecutive draws, during which they have drawn a blank twice.
Graham Alexander's Fleetwood Town could also find themselves in top spot if they beat York City, who have failed to find the back of the net in their last three outings.
Keith Hill's men have won four of their last six in League Two and will be buoyed after coming back from two goals down in injury time to draw at Chesterfield in their last league game.
Oxford's first home game since the departure of Wilder sees them entertain AFC Wimbledon.
Phil Brown's Southend United are the third side on 46 points and will look to keep up their recent form by defeating Newport County on Friday.
