James Troisi scored twice as the visitors recovered from Bernie Ibini's opener, with Archie Thompson also on target for the Victory.
The Mariners were left to rue a controversial decision from referee Matthew Gillett, who only awarded a free-kick when Mile Sterjovski was brought down by Pablo Contreras apparently inside the area when the home side trailed 2-1.
Ibini put the Mariners ahead with 11 minutes on the clock, turning home from close range after Nathan Coe had parried Joshua Rose's strike.
Still frustrated by that questionable call, Central Coast fell further behind in the 62nd minute as Troisi beat Liam Reddy at his near post.
First-half goals from Bruce Djite and Fabio Ferreira put United in control, with Jeronimo Neumann's late strike rounding off the scoring.
