Cruzeiro, Libertadores favourites who were also upset on Wednesday, lost their "clasico" against Atletico Mineiro 2-1 in the first leg of the Mineiro (Minas Gerais) state championship.
Santos, the only one of five Brazilian teams to qualify for the last eight of the Libertadores, held Corinthians 0-0 in the first leg of the Paulista in Sao Paulo but lost Paulo Henrique Ganso to injury.
Brazil playmaker Ganso suffered a thigh muscle injury that makes him doubtful for Wednesday's first leg of their Libertadores quarter-final away to Once Caldas in Colombia.
"Players should always be fit but with this tough series (of matches you risk) them ending up hurt. I'm always going to complain but it doesn't get us anywhere with this sort of bad luck," Santos coach Muricy Ramalho told reporters.
Ronaldinho's Flamengo won the Carioca (Rio de Janeiro) title last weekend in the season-opening state competitions, which come to an end before the May 21 start of the Brazilian championship.
'LITTLE PRACTICE'
"We're aware of what's happened but we haven't had time to work," said Inter coach and idol Falcao, who took charge last month.
"We've had seven deciders from the 17th until this Sunday with game after game. We can't train, we feel the lack of practice," he told reporters looking back over a run of key matches in two competitions.
The Mineiro final first leg at the Arena do Jacare (alligator's arena) in Sete Lagoas was decided in the first half with right-back Patrick scoring Atletico's winner eight minutes before halftime.
It ended with some arguing and pushing among players after Cruzeiro's Argentine playmaker Walter Montillo was sent off for elbowing Giovanni
