Ligue 1's bottom club have endured a nightmarish season, and stand on the brink of dropping into the second tier after a campaign that has seen them claim just three league wins.
And Christian Bracconi's men will need to take maximum points at the Stade Armand Cesari if they are to stand any chance of staying in the top flight.
However, Ajaccio have not emerged victorious in the Corsican derby since 2008, and even if Bracconi's side do beat Bastia, they will still be relegated should 17th place Guingamp - who are 15 points ahead of the islanders with five games remaining - win at Bordeaux.
That streak has left the Brittany club just five points above the relegation zone, and Jocelyn Gourvennec's men will be wary of 18th place Sochaux, who are on the charge after just three defeats in their last 12 league outings.
PSG are heavy favourites to successfully defend their Ligue 1 title, but Monaco trimmed the capital club's lead to 10 points last weekend by overcoming Rennes 1-0, while Laurent Blanc's men were beaten 1-0 at Lyon.
The league leaders face Lyon again in the Coupe de la Ligue final on Saturday, affording Monaco the opportunity to gain further ground ahead of PSG's clash with Evian next Wednesday.
Friday sees a rematch of last season's Coupe de la Ligue showpiece as Saint-Etienne host Rennes.
Saint-Etienne were victorious on that occasion, claiming a 1-0 victory at the Stade de France, and will look to replicate that triumph in order to keep their slim hopes of overhauling third-placed Lille alive.
