Claude Puel's side won 2-1 in the corresponding fixture in 2012-13 at the Stade du Ray in December 2012 thanks to a late winner from Valentin Eysseric, one of only five Ligue 1 defeats that PSG suffered en route to being crowned champions.
That victory was a standout moment in what was an excellent campaign for Nice, who finished fourth, qualifying for the UEFA Europa League.
However, Nice's chances of overcoming the runaway leaders at their new Allianz Riviera home appear slim following a change in fortunes.
Nice are unbeaten in the previous three league games, but still sit a disappointing 11th, 35 points behind PSG.
Laurent Blanc's men lead second-placed Monaco by 10 points following last week's 1-0 success at Lorient and should be confident of completing a league double over Nice after cruising to a 3-1 win in the reverse fixture in November.
But, despite the capital club's dominance in domestic competition, Ospina insists Nice will be determined to cause an upset.
"We know their quality, we know that they are en route to the title and have shone in the Champions League," Ospina said.
"But ultimately it is only one more reason to give our maximum and pull off a result. We are working to make progress, to take points.
"Throughout the week we have done a lot of work, now we want to finish it on Friday."
However, with the visit of Premier League leaders Chelsea around the corner, Blanc could well rest a number of his stars for the trip to the Cote d'Azur.
