PSG were knocked out of Europe in heart-breaking fashion on Tuesday, suffering a 2-0 quarter-final second-leg defeat to Chelsea, who went through on away goals after levelling the tie at 3-3 late on at Stamford Bridge.
That loss ended hopes of a quadruple for Laurent Blanc's side, who have already won the Trophee des Champions this season and are in pole position to claim a second straight Ligue 1 title.
The capital club travel to the Stade de Gerland - the scene of last season's title triumph - 13 points above second-placed Monaco, and will be keen to gain a psychological edge over Lyon on Sunday ahead of the Coupe de la Ligue showpiece at the Stade de France the following Saturday.
Rennes meet Ligue 2 Angers in next Wednesday's semi-final, while Monaco are favoured to overcome Guingamp and reach the showpiece.
But the principality club's immediate focus will be on holding off third-placed Lille, who are just six points behind Claudio Ranieri's men with as many games to go.
Evian welcome Bastia to Annecy with Pascal Dupraz's side seeking to make it four games unbeaten.
Meanwhile, bottom club Ajaccio will definitely be relegated if they lose to Bordeaux, but at the other end Saint-Etienne travel to Reims as Christophe Galtier's men try to keep pace with Lille in the race for the final Champions League place.
