"We'll watch a game performed in two very different styles. Bremen are an attacking side with very good physique. They have some very strong athletes on the team," he said.
"Shakhtar Donetsk's style is based on the good technique of our players and we will try and control the game," the Romanian told a news conference on Tuesday.
By contrast Werder Bremen, Cup Winners' Cup winners in 1992, have been hit with a host of suspension and injury problems.
"I would like to have seen how the Brazilian players would have faced each other," said Lucescu, whose squad features five Brazilians.
Shakhtar, who beat Barcelona 3-2 at the Nou Camp in the Champions League last December, have helped boost the level of Ukrainian football, he added, building on the country's profile before it co-hosts Euro 2012 with Poland.
From next season UEFA's second-tier competition becomes the Europa League, a rebranded and expanded affair that European football's governing body hopes will give it renewed impetus.
The venue is familiar to Lucescu who had spells in charge of Fenerbahce's Istanbul rivals Galatasaray and Besiktas.
"This is a city I love a lot," he said. "I was here for four years and those years brought me a lot of happiness. They were good years in my professional career."
