Leaders Manchester City can win the title if they are able to cope with the impending departure of brothers Kolo and Yaya Toure to the Africa Cup of Nations, manager Roberto Mancini said.
"If, when Kolo and Yaya Toure come back from the African Cup and we are top, I think we can win the title," Mancini told a news conference on Friday as City prepare for the visit of Arsenal on Sunday.
City lost for the first time in the league this season on Monday at Chelsea and in-form Arsenal will present a stern test for Mancini's side, who will be without former Arsenal player Gael Clichy who is suspended.
"He had a very important scan on Thursday and that was very, very good. Exceptionally good. The news we have for Jack is very positive," Wenger said.
Andre Villas-Boas is targeting a fourth consecutive league win in the Premier League as his third-placed Chelsea side travel to third-from-bottom Wigan Athletic on Saturday. "If we can get the win we want and expect it means maybe we are in our best period of the season," the Portuguese said.
Aston Villa will be without Gabriel Agbonlahor for Sunday's home match against Liverpool because of a one-match ban for accumulating five yellow cards.
Manager Alan Pardew has called on the Newcastle fans to give his side a boost. "It will be about making sure that when they come to our stadium they feel the impact of it," Pardew said.
"It's a big stage and for their players it will be their first time. I think that is an advantage for us."
