The Group G clash between Europe's two most successful clubs has all the ingredients of a classic encounter, most notably Real coach Jose Mourinho making his first return to the San Siro since leaving Inter Milan after securing the European Cup.
Milan's Ronaldinho, an old adversary of Real from his glittering spell at Barcelona, is also hoping to make a decisive comeback from injury and stop the visitors sealing their place in the last 16 with a first win at the famous stadium.
First, Real completely steamrollered the Rossoneri in the first quarter of the Bernabeu group game with the red-hot Cristiano Ronaldo and Mesut Ozil scoring within a minute to wrap up an easy 2-0 win two weeks' ago.
"At Madrid we deserved to lose, against Juve we didn't but football is like that. We definitely have to analyse the reason we are losing big games," said coach Massimiliano Allegri, a former Cagliari boss who is a novice at the very top level.
Zlatan Ibrahimovic, the pillar of Milan's trident attack, at least broke one duck on Saturday when he scored against former club Juve for the first time after two years trying with Inter.
"It's important for us to still be group leaders after our game in Milan. Our goal is to secure the first position as soon as possible and that's why it's important to earn a good result there," the Portuguese told a news conference.
"We were better than them at the Bernabeu and they will want to prove they can defeat us."
