The Portuguese international picked up the injury just over a week ago and was left out of the squad for Real's La Liga clash at home to struggling Hercules on Saturday.
"I think he'll play, but I don't like it when players aren't 100 percent," Mourinho told a news conference.
"If he had to play tomorrow he wouldn't be, but if he trains Saturday, Sunday, Monday and Tuesday I'm convinced he'll be able to play."
"It isn't the same for everyone," Mourinho said.
"I'm not stupid and we all know that if the gap between the teams grows bigger the championship is lost.
"When one team plays in the Champions League on Tuesday and in the league on Sunday (Barca), and the other on Wednesday and then Saturday, they aren't giving Real Madrid the same chances to compete."
