The winger missed the squad's final home training session in Portugal on Saturday after falling while attempting an acrobatic shot and causing a traumatism in his shoulder.
He is due to be re-examined before the warm-up match against Mozambique on Tuesday.
"I feel better already," Nani told reporters during the flight from Lisbon to Johannesburg.
On playing in the friendly, he said: "I really don't know, now we have to see. When we get there we'll have to check again."
"I'm in the group. I'm here to help and now the matter is in the coach's hands," Pepe said as he boarded the plane.
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