Leaders Olympique Lyon are once again short of options in defence for the visit of Sochaux on Sunday.
Brazil centre back Cris is suspended, France's Jean-Alain Boumsong and Ghana's John Mensah are doubtful through injury and right wing back Francois Clerc is struggling for form after a seven-month absence.
Senegal striker Mamadou Niang and Ivory Coast forward Bakari Kone both came back from injury during Wednesday's 2-2 draw at Ajax Amsterdam in the UEFA Cup. They will vie for a place up front with Brazilian Brandao, France's Hatem Ben Arfa and Mathieu Valbuena.
Lille players will observe a minute's silence before they take on Grenoble on Saturday. They will also wear black armbands in memory of two fans killed by a train after a Ligue 1 game against Lyon at the Stade de France two weeks ago.
Both players are suspended after being shown direct red cards in Lille's penalty shootout defeat at Toulouse in the French Cup quarter-finals on Tuesday.
