Rooney has been sidelined since injuring his ankle against West Bromwich Albion on New Year's Day, while captain Vidic was rested in last week's 1-0 win over Liverpool in the FA Cup.
"We have Wayne and Nemanja training, they should be fit for Sunday," Ferguson told a news conference at United's training ground on Friday.
"Edwin van der Sar is a possible, he should be training today, so really going into such a big game we have a good squad available to us, which is nice. We've had a week's rest, as have Tottenham, and it should be a really fantastic game.
The trip to White Hart Lane is widely seen as unbeaten United's biggest challenge so far this season. Fourth-placed Spurs are eight points behind the leaders.
"Gareth has missed a couple of days training but he should be okay," Redknapp told reporters on Friday. "We're in good shape. We've pretty much a full squad."
