Antonio Conte's team, fresh from securing a third successive Scudetto, require a draw at second-placed Roma to tie Inter's record points haul of 97 for a season - set in 2007 - before they round off their campaign at home to Cagliari next week.
Victory at Stadio Olimpico would keep Juve on course for the 100-point mark, but Roma - who have racked up 85 points from their 36 fixtures so far this term - are undefeated at home this season.
Juve have also lost 1-0 on their last two visits to face Roma, but will take heart from the fact they won the reverse game 3-0 back in January.
With the top three positions already settled - Napoli, who travel to out-of-form Sampdoria on Sunday, are assured of finishing third - attention can turn to the battle for UEFA Europa League qualification.
Fiorentina, who visit bottom-placed Livorno, are all but certain to end the season in fourth, meaning Inter, Torino, Parma, Milan, Verona and Lazio are fighting it out for two Europa League spots.
And two matches this weekend will have a big say on who qualifies for continental competition.
The outstanding form of winger Alessio Cerci and Ciro Immobile - Serie A's leading scorer - have helped sixth-placed Torino take 16 points from their last six games, and victory at home to Parma could secure the Turin outfit European football for the first time in 20 years.
Meanwhile, Lazio are the guests at Inter legend Javier Zanetti's San Siro swansong on Saturday.
Fifth-placed Inter have lost their last four matches against Lazio, who sit just four points behind them in 10th, and go into the game on the back of a derby defeat to rivals Milan last week.
