Antonio Conte's men are closing in on a third Scudetto in a row after extending their unbeaten run in the league to 22 matches with a 2-1 win over Parma on Wednesday - a game that also saw them set an Italian top-flight landmark with a 15th straight home win.
They now sit 14 points clear of second-placed Roma with eight games remaining, while Napoli are a further six points adrift and know that another defeat will officially spell the end of any lingering hopes of a miraculous championship challenge.
Napoli's recent loss to Fiorentina saw them fall further behind the league leaders after their early-season promise had faltered from mid-January and into February.
A third home defeat of the league campaign would leave Rafael Benitez's side 23 points behind the leaders with only 21 available, meaning that only Roma could stop the Juventus juggernaut.
In reality, Benitez has long since conceded the title, but he will at least look to mastermind Napoli's first league win over Juve since January 2011, a run of six matches.
"I'm sad to be missing out on Napoli," he said.
"I always want to be involved in every game. On the plus side, I'll be fresh for Lyon (in the Europa League)."
