Universitario visit Libertad, Paraguayan champions four times in a row, on Wednesday as the group stage kicks off in the region's equivalent of the Champions League.
Solano's signing was considered a major coup for Universitario, who have been mired in financial problems and last year struggled to pay their players on time.
He is one of the highest-profile South American players to return home since Argentina's Juan Sebastian Veron joined Estudiantes in 2006.
"Solano's presence for Universitario is similar to Veron in Estudiantes," warned Libertad coach Javier Torrente.
Of the 18 teams in action this week, none will be under more pressure than Argentina's River Plate who host Paraguay's Nacional in a Group Three match in Buenos Aires on Thursday.
River finished bottom of the Apertura championship in the second half of last year and began this year's campaign by squandering a 2-0 lead in a 2-2 draw at home to 10-man Colon on Sunday, their first match under new coach Nestor Gorosito.
Guadalajara are Mexico's most popular club and the only one not to field foreign players.
