America, the country's richest club, replaced Carlos Reinoso (pictured) with Alfredo Tena and Guadalajara-based Atlas appointed Juan Carlos Chavez after Argentine Ruben Omar Romano resigned.
Estudiantes Tecos, Queretaro and Santos Laguna have also changed coaches since the 18-team Apertura, the first of two championships in the Mexican season, started in late July.
Six points from nine games sealed Del Olmo's fate at Tijuana, though his achievements were recognised and appreciated by the club.
"The directors give enormous thanks to Del Olmo's work," said Tijuana in a statement shortly after Sunday's 2-0 home defeat by Estudiantes Tecos.
"He brought the Tijuana team into the first division of Mexican football and that is something that will always be recorded in the illustrious history of this border town."
'Captain Fury', who has also coached Santos Laguna, Puebla, Pachuca, Queretaro and Veracruz, will make his debut with the Eagles against Tijuana on Saturday.
