Striker Wayne Rooney has been ruled out of Manchester United's match against Bolton on Saturday with a calf injury but goalkeeper Edwin van der Sar is expected to return.
Rooney missed England's final World Cup qualifying match on Wednesday against Belarus.
"Rooney's out, that's the one certainty," manager Alex Ferguson told the club's website on Friday. "We're doing our best to get him fit for Wednesday (against CSKA Moscow) but I've got my doubts."
Ferguson was confident however that Van der Sar could make his first competitive start for United this season after breaking his finger in a pre-season friendly against Bayern Munich.
"Edwin's fit and he plays tomorrow," Ferguson said.
Liverpool duo Fernando Torres (abdomen) and Steven Gerrard (groin) are out of the trip to Sunderland on Saturday after failing to recover from injuries picked up on international duty.
"Both Steven and Fernando still have some problems. They will need more time and won't be available this weekend," manager Rafael Benitez told the club's website on Friday.
"I think they could be available for next week," Benitez added.
Goalkeeper Manuel Almunia could return for Arsenal for the clash with Birmingham City on Saturday after a chest infection.
"Almunia could be available for the game. It is 50/50," manager Arsene Wenger told the Arsenal website on Thursday.
Croatian striker Eduardo has been ruled out (thigh) and French defender Gael Clichy (ankle) is a doubt.
Birmingham City's Ecuadorian striker Christian Benitez will miss the trip to the Emirates Stadium after missing his flight back from Chile where he was on international duty.
Manchester City manager Mark Hughes has a host of injury worries ahead of his side's clash with Wigan Athletic on Sunday.
Joleon Lescott (calf), Kolo Toure (heel), Craig Bellamy (groin) and Martin Petrov (knee) are all doubts.
"Joleon will be out with the physios today, and we're more hopeful on him than on Kolo in fairness," Hughes told the club's website on Friday.
Tottenham Hotspur defenders Jonathan Woodgate, Ledley King and Michael Dawson could all return from injury for their match against Portsmouth on Saturday.
"Suddenly we've three more fantastic centre-halves available. That makes us stronger," said manager Harry Redknapp.
Wolverhampton Wanderers manager Mick McCarthy has strikers Michael Kightly and Sylvan Ebanks-Blake available after injury for his team's trip to Everton on Saturday.
Everton's Belgian midfielder Marouane Fellaini is available after missing his country's 2-0 defeat to Estonia on Wednesday to have surgery to remove a wisdom tooth.
