Midfielders Fabian Delph and Karim El Ahmadi missed the 2-1 home defeat to Fulham last weekend with a sore leg and thigh strain respectively, while forward Gabriel Agbonlahor was absent through illness.
However, manager Paul Lambert is hopeful that all three will be available as Villa face Tony Pulis' men looking to end a run of three straight losses.
"There will be a good chance the three of them will be back next week," Lambert told the club's official website.
"We had Fabian missing against Fulham and Gabby (Agbonlahor) too and Karim, who has been playing really well of late. These are lads who have played a lot of the season."
Lambert lamented Villa's ill-fortune this season, with Christian Benteke the latest long-term casualty after suffering a serious Achilles injury.
In addition to Benteke's setback, Jores Okore sustained a ruptured anterior cruciate ligament in September and Libor Kozak broke his leg during training in January.
Lambert added: "It's been a big chunk of our squad. If you go through them - Jores has virtually missed the whole season, Libor has missed half a season, Christian is out for six months or so.
"There's been major, major injuries. It's not like they have been strains. These have been big injuries."
Villa have received positive news regarding striker Nicklas Helenius, who is nearing a first-team return and could resume training this week.
"Nicklas has had a thigh strain - an abductor strain," he continued. "He might begin training at the start of the week.
"He has had little injuries which have kept him out. But hopefully he will train this week."
Get the best features, fun and footballing frolics straight to your inbox every week.
Thank you for signing up to Four Four Two. You will receive a verification email shortly.
There was a problem. Please refresh the page and try again.