Julen Lopetegui's men host the Belarusian outfit in what will be their 200th fixture in Europe's premier club competition.
The hosts will be expected to claim a straightforward victory at Estadio do Dragao and confidence is likely to have been heightened by the return of Sandro, who has become a mainstay at left-back for the Portuguese club in recent seasons, to training.
Sandro had been out of action since the 2-0 victory over Lille in the second leg of the play-off round last month due to a thigh problem but, while his prospective comeback is good news for Lopetegui, Porto's Spanish coach still has plenty of injury troubles to contend with ahead of the encounter.
Indeed, on-loan Barcelona forward Cristian Tello also has a thigh concern and is a doubt, while teenage midfielder Oliver Torres (shoulder) and attacker Goncalo Paciencia (knee) are set to miss out.
A clash with BATE represents a new frontier for Porto, who have never faced Alyaksandr Yermakovich's men before.
Porto are favourites to win what appears to be an open Group H that also features Athletic Bilbao – making their first appearance in the tournament since 1998 – and Shakhtar Donetsk.
Their finest moment in the Champions League came in 2012-13 when BATE overcame eventual winners Bayern Munich 3-1 at home to claim a famous victory.
Few will envisage BATE pulling off a similar upset in Portugal on Wednesday, especially after a qualifying campaign that saw them limp through ties with Skenderbeu and Debrecen before ensuring their place in the group stage with a 4-1 aggregate win over Slovan Bratislava.
