Laurent Blanc's men will progress from Group F if they beat APOEL at Parc des Princes on Wednesday and Ajax fail to defeat Barcelona.
Qualifying for the last 16 of Europe's premier club competition would leave PSG in buoyant mood ahead of their top-of-the-table encounter with Ligue 1 leaders Marseille on Sunday.
However, the French champions will not need reminding of how stern a task they face having struggled to a 1-0 win in Cyprus in the reverse fixture just over a fortnight ago.
The Uruguayan is likely to once more head PSG's attack in the absence of talisman Zlatan Ibrahimovic, who has been sidelined since late September with a foot injury.
Giorgos Donis' men have proven stubborn in Europe, though, with their goal breached on just three occasions in those three outings.
Goals at the other end have proved hard to come by for APOEL too, and their solitary goal came in the 1-1 draw against Ajax on September 30.
As well as a lack of firepower, APOEL will also have to overcome PSG's fantastic record on home soil in Europe.
APOEL also have several injury worries.
