The defending champions enhanced their status as the most successful European club of all time when they beat neighbours Atletico Madrid to collect a 10th Champions League crown last May.
Victory over Schalke would be Real's 11th successive win in the competition, following a 2-0 triumph in the first-leg of the last-16 tie in Gelsenkirchen last month, and this would represent a new Champions League record.
Additionally, Carlo Ancelotti's men are chasing a record-equalling 12th straight home win in Europe's premier club tournament, although they will do so following a domestic setback at the the weekend.
Defeat to Athletic followed a 1-1 draw against Villarreal and Ancelotti has urged his all-star attack to start firing again as soon as possible.
"The team is compact and focused on the targets that we have to keep fighting for," he said, as quoted on Real's official website.
"We have to fix the problems quickly. It sounds strange to say that Real Madrid has attacking problems when we have scored so many goals this season, but it is the truth."
Christian Fuchs opened the scoring at the weekend and told Schalke's official website: "We head to Madrid in high spirits.
"No one will be betting on us to turn it around, but there's a chance that it could happen."
Kevin-Prince Boateng's booking during the first leg means he is unavailable to Schalke coach Roberto Di Matteo due to suspension.
