Clarke's men slumped to a 4-1 defeat at Anfield and were already on the wrong side of a Luis Suarez double by the time Amalfitano pulled up shortly before half-time.
The Marseille loanee was unable to make it to half-time for an assessment and made way for James Morrison in the 44th minute.
Morrison pulled a goal back from the penalty spot after Suarez completed his hat-trick but Daniel Sturridge sealed West Brom’s misery with a magnificent 25-yard lob.
"I'm not sure," said Clarke when asked about Amalfitano's condition. "I've not really had a chat with the doctor.
"He was indicating that he had an injury. We tried to get him to half-time but he said it was too bad, so we made the change.
"We'll assess him and see what the problem is."
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