Clint Dempsey Goals from Matt Polster, Juninho, Michael de Leeuw and Luis Solignac helped red-hot Chicago Fire to a ninth successive home win in MLS.
Tigres UANL and Club America made it four Mexican teams in the CONCACAF Champions League semifinals.
New York City returned to winning ways in MLS as Didier Drogba's tremendous free-kick was not enough for Montreal Impact.
Benny Feilhaber New England Revolution recorded an overdue win, while Sebastian Giovinco produced an All-Star performance in MLS.
The LA Galaxy were held to a draw by DC United despite Zlatan Ibrahimovic's 10th goal of the MLS season.
Clint Dempsey Cyle Larin was at the double to guide Eastern Conference leaders Orlando to a 2-1 victory at NYC in the Big Apple on Sunday.
David Villa Sánchez New York City claimed back-to-back wins for the first time in their history, while New England Revolution stayed in touch with DC United.
Seattle Sounders Seattle claimed the Western Conference lead with victory while Toronto FC produced a stirring fightback to win in Saturday's MLS action.
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